AIEgen-based theranostic system: targeted imaging of cancer cells and adjuvant amplification of antitumor efficacy of paclitaxel† †Electronic supplementary information (ESI) available: Experimental procedures, structural characterization data and absorption spectra of compounds, as well as cell imaging results. See DOI: 10.1039/c6sc03859j Click here for additional data file.

نویسندگان

  • Chao Chen
  • Zhegang Song
  • Xiaoyan Zheng
  • Zikai He
  • Bin Liu
  • Xuhui Huang
  • Deling Kong
  • Dan Ding
  • Ben Zhong Tang
چکیده

Key Laboratory of Bioactive Materials, Mini Medicinal Chemical Biology, College of L 300071, China. E-mail: [email protected]. Department of Chemistry, Hong Kong B Research Center for Tissue Restoration and Engineering, The Hong Kong University o Water Bay, Kowloon, Hong Kong, China. EDepartment of Chemical and Biomolecul Singapore, 4 Engineering Drive 4, Singapore † Electronic supplementary information (E structural characterization data and absor cell imaging results. See DOI: 10.1039/c6s ‡ These authors contributed equally to th Cite this: Chem. Sci., 2017, 8, 2191

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AIEgen-based theranostic system: targeted imaging of cancer cells and adjuvant amplification of antitumor efficacy of paclitaxel.

Photosensitizers are generally treated as key components for photodynamic therapy. In contrast, we herein report an aggregation-induced emission luminogen (AIEgen)-based photosensitizer (TPE-Py-FFGYSA) that can serve as a non-toxic adjuvant to amplify the antitumor efficacy of paclitaxel, a well-known anticancer drug, with a synergistic effect of "0 + 1 > 1". Besides the adjuvant function, TPE-...

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عنوان ژورنال:

دوره 8  شماره 

صفحات  -

تاریخ انتشار 2017